M.Sc 407 Inorganic Chemistry

 M.SC Sem 2 P-407 INORGANIC SYLLABUS

Gujarat University

UNIT 1 -  Theories of Bonding

• VSEPR. ↗
• Walsh diagram for tri-atomic molecules. ↗
• Bent rule and energies of hybridization.
• VSIP.
• Simple Huckel theory of linear conjugated systems.
• cyclic conjugated systems aromaticity.
• Many electron atoms and angular momenta: The Wave function of many  electron systems.
• Application to helium atom.
• Hartree Self-Consistent field method. 
• Pariser-Parr-Pople appoximation.

CHE 2 - Applications of Symmetry

• Molecular spectroscopy and Vibrational spectroscopy: Reducible representation using 3N vectors as the basis.
• symmetry selection rules for IR and Raman spectroscopy.
• Classification of vibrational modes using internal coordinates as the basis and assignment of frequency to fundamentals.

• Molecular symmetry and chemical bonding: hybrid orbitals for σ-bonding and  π-bonding in ABn type of molecules.

• Symmetry Adopted Linear Combination of Atomic orbitals: Projection operator for finding SALC.
• Bond vectors as the basis for formation of SALC.
• Orbital functions as the basis for obtaining SALC. 

UNIT 3 - Bioinorganic Chemistry

• Hemoglobin and Myoglobin;
• Cytochromes of the electron transport chain, 
• Cytochrome P-450 enzymes,
• Coenzyme B12,
• Zinc Enzymes exploiting acid catalysis: Carbonic anhydrase, Carboxy peptidases, 
• Biological Nitroge Fixation,
• The elements of living system: The biological roles of metal ions

Metals in medicine:

• Chelation Therapy,
• gold in Rheumatoid antiarthritis drugs
• Metallocenes,
• Anticancer agents- Platinum complexes ,
• mechanism of action,
• aspects of Pt binding to DNA,
• Metal complexes as radiodiagnostic agents,
• Magnetic resonance imaging

Metal-nucleic acid interactions: 

• Coordination,
• Non-covalent interactions -intercalation and hydrogen bonding,
• hydrophobic interactions,
• DNA strand cleavage,
• Biological fluorophores,
• Application of fluorescence quenching in drug-DNA binding studies.
• DNA binding and mechanistic possibility.

UNIT 4 - Metal-Ligand Equilibria

Types of Complex Equilibria in Solution and Equilibrium Constants:

• Basic principles,
• Mathematical functions and their interrelationship.

• Statistical considerations.
• Factors affecting the stability constants of Metal complexes. 
• Mixed-ligand complexes.

Experimental Methods for the Determination of Stability Constants:

• Ion exchange methods.
• Polarographic methods.
• Solubility methods and Least square method for computing stability constant.