M.Sc 408 Organic Chemistry

 

M.SC Sem 2 P-408 ORGANIC SYLLABUS

Gujarat University

Unit 1 Photochemistry

1. Mechanism, Photochemical reactions: Principles of energy transfer, electronic excitation

2. Characteristics of photochemical reactions

3. Jablonski diagram

4. Chemiluminescence, Bioluminescence

5. Photosensitization

6. Photochemistry of carbonyl compounds: Representation of excited states of  ketones

7. Photoreduction 

8. Norrish type Ι & II reactions, Reactions of cyclic Ketone and acylic Ketone

9. Oxetane formation (Paterno-Buchi reaction) 

10. Di-π methane rearrangement

11. cis-trans isomerisation 

12. Photo-Fries rearrangement

13. Applications of photochemistry

Unit 2 Heterocyclic Compounds

1. Introduction

2. Nomenclature of Heterocyclic compounds

3. Pyridine conceptually derived from Benzene, replacing CH with N

4. Pyrrole derived from benzene, replacing CH=CH with N 

5. Reactions of Pyridine and its derivatives

6. Reactions of Pyrrole and its derivatives 

7. Comparison of Pyrrole with furan and thiophene 

8. Chemistry of Imidazole, Triazoles, Tettrazole

9. Fused rings: indole, quinoline, isoquinoline, and indolizine 

10. Chemistry of Oxazole, Thiazole, Isoxazole, Isothiazole

11. Importance of heterocyclic compounds in medicinal chemistry

Unit 3 Name Reactions 

​Total 10 name reactions and their principle, general reaction, mechanism, synthetic application, advantages, disadvantages and modification-scope of reaction.

1. Suzuki reaction 

2. Sonogarshira coupling

3. Bhuchwald -Hartwig reaction 

4. Knoevanagel reaction

5. Shapiro reaction

6. Ugi reaction

7. Biginelli reaction

8. Nazerov cyclization

9. Ullmann reaction.

10. Baylis Hilman

Unit 4 Reagents in organic synthesis

Total 10 reagents, mechanism, selectivity and utility of following reagents:

1. HATU 

2. Lithium diisopropylamide (LDA)

3. Dicyclohexyl carbodiimide (DCC)

4. 1,3 – Dithiane (Umpolung reagent)

5. Dess- Martin periodinane

6. Diisobutylauminium hydride( DIBAL –H)

7. Sodium cyanoborohydride (NaBH3(CN))

8. DDQ

9. n-Butyl lithium

10. Phase transfer catalysis : Quaternary ammonium and phosphonium salts, crown ethers.