NAME REACTIONS -( Unit 3 )M.SC 408 ORGANIC CHEMISTRY

 Unit 3 Name Reactions 

M.SC Sem 2 P-408 ORGANIC SYLLABUS

-Gujarat University  syllabus 

​Total 10 name reactions and their principle, general reaction, mechanism, synthetic application, advantages, disadvantages and modification-scope of reaction.

1. Suzuki reaction 

2. Sonogarshira coupling

3. Bhuchwald -Hartwig reaction 

4. Knoevanagel reaction

5. Shapiro reaction

6. Ugi reaction

7. Biginelli reaction

8. Nazerov cyclization

9. Ullmann reaction.

10. Baylis Hilman

Let's explain one by one. Hear we provide a little discription about all reactions. also their pdf.

1. Suzuki reaction - 

• The Suzuki reaction is the coupling of an aryl or vinyl boronic acid with an aryl or vinyl halide or triflate using a palladium catalyst. It is a powerful cross-coupling method that allows for the synthesis of conjugated olefins, styrenes, and biphenyls.

2. Sonogarshira coupling

• The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon–carbon bonds. It employs a palladium catalyst as well as copper cocatalyst to form a carbon–carbon bond between a terminal alkyne and an aryl or vinyl halide.

3. Bhuchwald -Hartwig reaction 

• The Buchwald–Hartwig amination is a chemical reaction used in organic chemistry for the synthesis of carbon–nitrogen bonds via the palladium-catalyzed coupling reactions of amines with aryl halides.

4. Knoevanagel reaction

• A Knoevenagel condensation is a nucleophilic addition of an active hydrogen compound to a carbonyl group followed by a dehydration reaction in which a molecule of water is eliminated (hence condensation). The product is often an α,βunsaturated ketone (a conjugated enone).

5. Shapiro reaction

• The Shapiro reaction or tosylhydrazone decomposition is an organic reaction in which a ketone or aldehyde is converted to an alkene through an intermediate hydrazone in the presence of 2 equivalents of organolithium reagent.

6. Ugi reaction

• The Ugi four-component condensation (U-4CC) between an aldehyde, an amine, a carboxylic acid and an isocyanide allows the rapid preparation of α-aminoacyl amide derivatives. The Ugi Reaction products can exemplify a wide variety of substitution patterns, and constitute peptidomimetics that have potential pharmaceutical applications. This reaction is thus very important for generating compound libraries for screening purposes.

7. Biginelli reaction

• This acid-catalyzed, three-component reaction between an aldehyde, a ß-ketoester and urea constitutes a rapid and facile synthesis of dihydropyrimidones, which are interesting compounds with a potential for pharmaceutical application.

8. Nazerov cyclization

• The Nazarov cyclization reaction (often referred to as simply the Nazarov cyclization) is a chemical reaction used in organic chemistry for the synthesis of cyclopentenones.
• The reaction is typically divided into classical and modern variants, depending on the reagents and substrates employed.

9. Ullmann reaction

• The Ullmann reaction or Ullmann coupling is a coupling reaction between aryl halides. Traditionally this reaction is effected by copper, but palladium and nickel are also effective catalysts.

10. Baylis Hilman

• This coupling of an activated alkene derivative with an aldehyde is catalyzed by a tertiary amine (for example: DABCO = 1,4-Diazabicyclo[2.2.2]octane). Phosphines can also be used in this reaction, and enantioselective reactions may be carried out if the amine or phosphine catalyst is asymmetric.

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