CHE (Organic) P-501 : Natural Products and Bio molecules (Semester 3 )

CHE(O) 501 

Natural Products and Bio molecules

Unit I: Steroids and hormones

• Introduction,
• Biogenesis of Steroids,
• Chemistry of cholesterol and ergosterol (no synthesis),
• Chemistry and synthesis of sex hormones (Testosterone,
• Oestrone, Progesterone) from cholesterol,
• Partial synthesis of Cortisone,
• Chemistry of bile acids,
• Plant hormones (auxins, heteroauxins, gibberellins)

Unit – II -Protein and peptides

• Introduction of protein,
• Stereoisomerism in α-amino acid,
• Acid-base properties of amino acid,
• Isoelectric Points and Electrophoresis,
• Reductive Amination,
• Structure and nomenclature of peptides,
• Classification of amino acids,
• Disulfide linkages in peptides,
• Amino acids sequence determination in polypeptide,
• Modern synthetic approach for end group analysis,
• Solution-phase peptide synthesis,
• Solid-phase peptide synthesis.

Unit – III-Carbohydrates

• Introduction & definition, 
• Classification,
• Types of glycosidic linkage,
• Chemistry of cellulose,
• Chemistry of starch,
• Chemistry of glycogen,
• Configuration of monosaccharides,
• Ring structure of monosaccharides,Disaccharides, Derivatives of polysaccharides.

Unit – IV -Nucleic acid and Fatty acid 

• Compounds of nucleic acids,
• nomenclature of nucleotides,
• nucleosides,
• structure of DNA & chemical parameters,
• DNA,
• proteins,
• structure of RNA,
• chemical synthesis of purine nucleobases,
• Prebiotic chemistry,
• Synthesis of nucleosides,
• Chemistry of polymerase chain reaction,
• DNA sequencing: Sanger’s di-deoxy method,
• Fatty acids,
• saturated fatty acids,
• unsaturated fatty acids,
• essentials fatty acids.

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Learning objective:

1. To understand the concept of biomolecules and natural product.
2. To understand the natural and synthetic pathways of the biomolecules and natural product.

Learning Outcomes

1. Learner can understand different types of steroids and hormones.
2. From Protein and peptides students will learn the topic and understand the importance of the same.
3. Study of different types of carbohydrates and their structures.
4. Students will learn the importance of nucleic acid in the DNA, RNA and proteins.