CHE (Organic) P-504 : Medicinal & Industrial Chemistry (Semester 3 )

CHE(EO) 504 ELECTIVE-1

Medicinal & Industrial Chemistry

-M.SC Syllabus  Gujarat University 2021-22

Unit – I -Drug Design, Antibiotics and antimalarial (with SAR, MOA)

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Drug Design

1. Introduction,
2. naming of organic medicinal compounds,
3. development of new drugs,
4. procedure (conventional and recent/modern) followed in drug design,
5. concept of lead compound and lead modification,
6. pro drugs, 
7. soft drugs and hard drugs,
8. phase I, II and III clinical trials,
9. structure activity relationship,
10. theories of drug activity : occupational theory, rate theory, induced fit theory, quantitative structure activity relationship.
11. Concept of drug receptors,
12. elementary treatment of drug receptor interactions,
13. physio chemical parameters lipophilicity,
14. partition coefficient,
15. electronic ionization constant.
16. Introduction to drug discovery by CADD - Structure and property,
17. ADME-rules,
18. concept of QSAR & 3-D QSAR,
19. Pharmacophore,
20. Enzymes/proteins structures/docking.
21. Software used in drug design.
22. Antibiotics and antimalarial (with SAR and MOA) 
23. Introduction, general classification, structural variations, synthesis and medicinal uses of the following :

•  Antibiotics: Penicillin, tetracycline, chloroamphenicol.
•  Antimalarial: Antimalarial agents based on 4-amino and 8-amino. 

Unit –II –Organic synthesis of imp drugs (psychoactive, cardiovascular, hypoglycemic, anti-TB, antimalarial)

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• Psychoactive drugs

1. Thiopental,
2. amobarbital,
3. diazepam,
4. chlorozepan,
5. alprazolam,
6. glutethimide,
7. nikethamide,
8. procaine,
9. lidocaine and dibucaine,
10. Ibuprofin,
11. meclofenate sodium,
12. novalgin, 
13. pethidine

• Cardiovascular, diuretics and hypoglycemic drugs

1. Synthesis of amyl nitrate,
2. diltiazim,
3. atenolol,
4. methyl dopa,
5. tolbutamide,
6. chloropropamide,
7. glibenclamide,
8. acetazolamide,
9. chlorothiazide,
10. furosemic and ethacrycnic acid 

• Antimalarial drugs

1. Mefloquines,
2. chloroquine,
3. primaquine and daraprim 

• Antituberculosis drugs

1. Isoniazid (INH),
2. Ethionamide,
3. Ethambutol,
4. DDS (Dapsone)

Unit – III- Basic principle and unit process (by Convention and Green chemistry aspects) in organic chemistry/industry

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Basic principle at chemical industry

•  Basic chemical data (including MSDS),
•  flow charts,
•  chemical process selection,
•  batch versus continuous operation.
•  Safety – general safety,
•  safety during handling of chemicals,
•  fire safety.
•  Hazardous - toxic chemical materials (Solid, liquid and gas),
•  precaution and action taken during accident by chemicals.
•  Patents and its importance in Research and development/chemical industry.
•  Good manufacturing practice (GMP) and Good laboratory practice (GLP)

Unit process (in organic chemistry) at chemical industry

• Nitration, Halogenation, Sulphonation and Amination methods and industrial chemicals derived from benzene,
• naphthalene using unit process by Convention and Green chemistry aspects (Green catalyst, Name reactions associated with green chemistry, one pot reaction, MCR, use of MW, Ultra sonic/sound) for each unit process with suitable examples. 

Unit – IV - Separation (chromatography & Unit operations) Techniques and Applications in organic chemistry

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Chromatography Techniques

• TLC, HPTLC, GC, HPLC/LC, SFC, Column Chromatography, Combi Flash 

Unit operations in organic chemistry –

• Filtration – Different types of filtration techniques, filter aid and filter media.

• Distillation - Different types of distillations with their pros and cons.

• Extraction – Solid from solids and liquid from liquids using suitable reagents.

• Drying – Using ovens, spray tower, plate and frame dryer

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Learning objectives :

1. Students will about the medicinal and industrial chemistry.
2. Learns will get knowledge of Drug design.
3. Learns can understand how to synthesis various drugs.
4. Learns can understand how to purify various products at Research (R & D) labs and industrial scale.

Learning outcomes :

1. Drug design is the important task since the discovery of drug and in future drugs are the need of the society. Learns will understand the concepts of how to develop drug.
2. Learns will understand what are antibiotics and where/when to use them.
3. The chemist (learns) should know how to synthesis the drugs by best route of synthesis.
4. For any chemical products the raw materials are required. The learns will learn how to synthesize the raw materials by green chemistry aspects.
5. Learns will learn that how to isolate and purify the products at chemical industries.